Translational Proteomics lab @ IRCM

Ongoing Projects

Unravelling the molecular basis of novel forms of hypomyelinating leukodystrophies

(with Geneviève Bernard, funded by CIHR) 

Keywords: RNA polymerase III, leukodystrophy, protein complex assembly

Towards Cell-based Interceptive Medicine: Combining proteome profiling and phage

display to track the phenotypic trajectory of cells during diabetes 

(funded by MEI, IRCM, and Winnermax Capital)

Keywords: Cell-based interceptive medicine, single-cell proteomics, early detection of diseases

The soluble fragment of neuroligin-1 as a blood biomarker of prodromal Alzheimer’s

disease 

(with Jonathan Brouillette, funded by the Weston Brain foundation)

Keywords: Alzheimer's disease, quantitative proteomics, biomarkers

Screening of chemical compounds that correct assembly defects of RNA polymerase III carrying a leukodystrophy-causing mutation 

(funded by the Québec Leuco dystrophie foundation)

Keywords: Riluzole, leukodystrophy treatment, correction of RNA pol III assembly defects, PAQosome

 

SELECTED PUBLICATIONS

Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III

Thiffault I, Wolf NI, Forget D, Guerrero K, Tran LT, Choquet K, Lavallée-Adam M, Poitras C, Brais B, Yoon G, Sztriha L, Webster RI, Timmann D, van de Warrenburg BP, Seeger J, Zimmermann A, Máté A, Goizet C, Fung E, van der Knaap MS, Fribourg S, Vanderver A, Simons C, Taft RJ, Yates JR 3rd, Coulombe B, Bernard G.

Nat Commun. 2015 Jul 7;6:7623. doi: 10.1038/ncomms8623.

How do our cells build their protein interactome?

Coulombe B, Cloutier P, Gauthier MS.

Nat Commun. 2018 Jul 27;9(1):2955. doi: 10.1038/s41467-018-05448-2.

De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy

Djordjevic D, Pinard M, Gauthier MS, Smith-Hicks C, Hoffman TL, Wolf NI, Oegema R, van Binsbergen E, Baskin B, Bernard G, Fribourg S, Coulombe B, Yoon G.

Am J Hum Genet. 2021 Jan 7;108(1):186-193. doi: 10.1016/j.ajhg.2020.12.002.

 
 

TEAM

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Dr. Benoit Coulombe

Director

Biography

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Dr. Esen Sokullu

Post Doctoral Fellow

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Christian Poitras

System Analyst

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Dr. Maxime Pinard

Senior Associate Researcher

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Asmae Moursli

PhD Student

Golden Marble

Vijaya Madoo

Administrative Assistant

 
 

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